CTC
Microsatellite instability (MSI) is a change in the length of a single, two, three, four or five nucleotide repeats in the genomic DNA of a tumor cell compared to the DNA of a normal tissue cell of the same individual.
Microsatellite instability
Microsatellite instability (MSI) is a change in the length of a single, two, three, four or five nucleotide repeats in the genomic DNA of a tumor cell compared to the DNA of a normal tissue cell of the same individual. Microsatellite instability exhibited by tumor tissues can be classified as high instability (MSI-H), low instability (MSI-L) and microsatellite stability (MSS) according to the degree of instability of the measured markers. The status of microsatellite instability in some samples can be verified by immunohistochemical detection of mismatch repair gene (MMR) deletion.
MSI-H mutation frequency in different tumors
Testing Advantages
Joint Lab
Pioneering the establishment of a joint laboratory with Promega in the United States in China.
New kit development
Use of Promega's newly developed MSI 2.0 kit and the conventional MSI 1.2 kit.
MSI 2.0 Kit Features
MSI 2.0 kit has more markers, a wider range of applications and higher detection sensitivity
Qualification
Qualified for US CAP certified MSI 2.0 and MSI 1.2 testing
Applicable people
Dosing guidance for chemotherapy (5-FU and Irinotecan) in patients with colorectal cancer.
For screening of patients with colorectal cancer.
For screening of patients with Lynch syndrome.
For patients with solid tumors in need of immunotherapy (PD-1 and CTLA-4).
Application Examples
Microsatellite instability in gastric cancer samples confirmed by immunohistochemical methods for the MMR gene.
Immunohistochemical method to identify deletion of MMR gene expression in gastric cancer samples (dMMR)
